Quantitative Susceptibility Mapping in Neuroinflammation,

Neurodegeneration, and Alzheimer Immunotherapy

Quantitative susceptibility mapping (QSM) advances MRI assessment of tissue magnetic susceptibility from qualitative detection of hypointense blooming artifacts to quantitative measurement of susceptibility distributions. By analyzing standard gradient-echo MRI data, QSM provides sensitive and specific information related to molecular electron cloud properties. The major susceptibility sources in brain tissue include paramagnetic iron, anisotropic diamagnetic myelin, isotropic diamagnetic proteins, and free water, all of which play important roles in cellular function and pathology. QSM therefore offers a powerful approach for studying diseases involving neurodegeneration, inflammation, and hemorrhage. This lecture will review QSM techniques and their applications to the assessment of brain iron,myelin, proteins, and free water in neuroinflammatory and neurodegenerative disorders, including multiple sclerosis and dementia. It will also discuss the use of QSM for evaluating cerebral microbleeds in the context of Alzheimer immunotherapy.

MRI Research Institute (MRIRI), Cornell University, New York, U.S.A.

The lecture will be held in sitem-insel (Room O2.211), Freiburgstr. 3, Bern followed by an Apéro and discussion and boroadcast virtually via Zoom at

https://unibe-ch.zoom.us/j/66256483922?pwd=aE1kTFg5aUZza1JmWEJxZDVsdnV5dz09

Please feel free to spread the word to anybody potentially interested.

For further info please contact: jessica.bastiaansen@unibe.ch

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